http://www.deadline.com/2010/08/ryan-reynolds-fits-safe-house-into-sked
Article highlights;
"the actor is now negotiating to play the young CIA agent who must transport a dangerous criminal (Washington) to safety after both are attacked at a safe house."
"Reynolds, who'll next be seen in the Rodrigo Cortes-directed thriller Buried--he is in every frame of the movie, trapped underground in a coffin beneath the sand in Iraq--will start work in October in The Change-Up, [CHNUP] the David Dobkin-directed Universal pic. If they can make a deal, Safe House follows early next year.